May 22

Leptin and Diseases

Leptin is the hormonal signal from fat, the energy store, to our brain. Many functions of our body, like growth and development, energy expenditure, bone health, reproduction etc., are influenced by leptin. Thus leptin is the link that connects our body functions to our food and our energy stores. Excessive production of leptin leads to leptin resistance that in turn can lead to abnormal functioning of all these systems.



Emerging Evidence

Leptin, leptin receptors, and the control of body weight. Friedman JM. Nutr Rev. 1998 Feb;56(2 Pt 2):s38-46; discussion s54-75. [See]

Selective leptin resistance: a new concept in leptin physiology with cardiovascular implications. Mark AL et al. J Hypertension. 2002;20(7):1245-1250.[See]

Obesity in the new millennium. Friedman JM.[See]

Etiology of the Metabolic Syndrome: Potential Role of Insulin Resistance, Leptin Resistance, and Other Players. Zimmet P et al. Ann NY Acad Scs 1999;892:25-44. [See]

The Metabolic Significance of Leptin in Humans: Gender-Based Differences in Relationship to Adiposity, Insulin Sensitivity, and Energy Expenditure.  Kennedy et al. J Clin Endo Met. 1997;82(4):1293-1300. [See]

Obesity, Body Fat Distribution, Insulin Sensitivity and Islet b -Cell Function as Explanations for Metabolic Diversity. Kahn SE et al. J Nutr. 2001;131:354S-360S. [See]

Adipocytokines and Insulin Resistance. Pittas AG, Joseph NA, Greenberg AS. JCEM 89(2)447-452. [See]

Abdominal obesity and metabolic syndrome. Després JP, Lemieux I. Nature 2006;444:881-888. [See]

Abdominal Obesity and the Metabolic Syndrome: Contribution to Global Cardiometabolic Risk. Després JP et al. Arteriosclerosis, Thrombosis, and Vascular Biology. 2008; 28: 1039-1049. [See]

Leptin mediates a proliferative response in human MCF7 breast cancer cells. Dieudonne MN et al. Biochemical and Biophysical Research Communications. 2002;293(1):622-628(7). [See]

Leptin is Associated with Increased Prostate Cancer Risk: A Nested Case-Referent Study.  Stattin P.JCEM. 86(3):1341-1345, [See]

Leptin and prostate cancer.  Chang S et al. Prostate. 2001;46(1):62-67. [See]

Leptin enhances, via AP-1, expression of aromatase in the MCF-7 cell line. Catalano S et al. J Biol Chem. 2003;278(31):28668-76. [See]

Association between Serum Leptin Concentrations and Bone Mineral Density, and Biochemical Markers of Bone Turnover in Adult Men. Sato M et al. JCEM 86(11):5273-5276. [See]

Leptin is Inversely Related to Age at Menarche in Human Females. Matkovic V et al. JCEM 1997;82(10):3239-3245. [See]

Role of obesity and leptin in the pubertal process and pubertal growth—a review. Shalitin S, Phillip M. International Journal of Obesity. 2003;27:869–874. doi:10.1038/sj.ijo.0802328 [See]

Link Between Body Fat and the Timing of Puberty. Kaplowitz PB. Pediatrics. 2008;121;S208. [See]

Are circulating leptin and luteinizing hormone synchronized in patients with polycystic ovary syndrome? Petermann TS et al. Hum Repro 1999;14(6):1435-1439. [See]

Overweight Kids Risk Weak Bones, Diabetes: Abdominal Fat May Play a Role in Bone Strength. Norman K Pollock et al. Lower bone mass in prepubertal overweight children with pre-diabetes Journal of Bone and Mineral Research Jul 2010 Abstract | Report]

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