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May 22

Problem of Insulin

High blood levels of insulin and resultant insulin resistance are identified to be at the root of several disorders, collectively called as Metabolic Syndrome. Both endogenous insulin and exogenous insulin, injected for treating diabetes mellitus, can cause problems. Keep your insulin levels low.

 

Emerging Evidence

Insulin causes more deaths than high blood glucose: ACCORD Study Finds
Full Text of ACCORD Study in NEJM 2008;358(24):2545-2559 | Full Text of the Editorial in NEJM 2008;358(24):2630-2633 | Diabetes & Obesity: Why Conventional Medicine Makes Things Worse By Mark Hyman in Huffingtonpost.com

Survival as a function of HbA1c in people with type 2 diabetes: a retrospective cohort study Like the ACCORD Study, one more British study involving 47970 diabetics above the age of 50 years finds that low and high mean HbA1c values are associated with increased all-cause mortality and cardiac events, meaning that both uncontrolled disease as well as intensive treatment can kill. Craig J Currie et al., The Lancet, Early Online Publication, 27 January 2010

Sulfonylureas and insulin increase the risk of pancreatic cancer: A case–control study of general practice patients in the United Kingdom suggests that the use of antidiabetics such as sulfonylureas and insulin is associated with an increased risk for pancreatic carcinogenesis. Bodmer M, Becker C, Meier C, Jick SS, Meier CR. Use of Antidiabetic Agents and the Risk of Pancreatic Cancer: A Case–Control Analysis. The American Journal of Gastroenterology. 31 January 2012; doi:10.1038/ajg.2011.483[Abstract][Report][Report]

Most drugs for diabetes, except metformin, are not safe: A review of available treatment options for diabetes has found evidence to support metformin as a first-line agent to treat type 2 diabetes, whereas other options are associated with increased risk for hypoglycemia and other adverse events. [Bennett WL et al. Comparative Effectiveness and Safety of Medications for Type 2 Diabetes: An Update Including New Drugs and 2-Drug Combinations. Annals of Internal Medicine May 2011;154(9)602-613. Full Text | Report]

Higher Blood Sugar Increases Cancer Risk: Abnormal glucose metabolism, independent of BMI, is associated with an increased risk of cancer overall and at several cancer sites, with stronger associations among women than among men, and for fatal cancer compared to incident cancer Stocks T et al., Blood Glucose and Risk of Incident and Fatal Cancer in the Metabolic Syndrome and Cancer Project (Me-Can): Analysis of Six Prospective Cohorts. PLoS Med 2009;6(12): e1000201 | Report

Elevated Insulin Linked To Increased Breast Cancer Risk: ReportMoreMore

Insulin Induced Hypoglycemia Kills: Mark Santos, a 25-year-old truck driver, was killed when he apparently could not control the truck he was driving, resulting in a fatal crash. Jordan Santos, his brother, said that Mark was a diabetic who sometimes had trouble remembering what he did when his blood sugar levels were low. Mark was likely in a hypoglycemic state when he lost control of the vehicle, according to his brother See Video: http://video.aol.com/video-detail/canada-truck-crash/917237579
The so called Human Insulin tends to cause hypoglycemia without warning and this tragic incident is a grim reminder of this fact. See Hypoglycemia and Human Insulin | Low blood sugar may impair diabetics’ driving: New Research Shows [See Full Text | Report]

Hyperinsulinemic diseases of civilization: more than just syndrome X [See]

Pathophysiology of Insulin Resistance and Noninsulin Resistance Dependent Diabetes [See]

Insulin and Its Metabolic Effects: Ron Rosedale [See]

Insulin Resistance Syndrome in Children. Ten S, Maclaren N. JCEM 89(6):2526-2539 [See]

Obesity, Insulin Resistance, Diabetes, and Cardiovascular Risk in Children. Circulation. 2003;107:1448. [See]

Insulin resistance syndrome (metabolic syndrome) and Asian Indians. Misra A, Vikram NK. Current Science 2002;83(12) [See]

Insulin through the ages: Phylogeny of a growth promoting and metabolic regulatory hormone. Chan SJ, Steiner DF.American Zoologist Apr 2000. [See]

Insulin: new roles for an ancient hormone. Ferrannini E et al. Eur J Clin Inv 1999;29(10):842-852(11) [See]

AMP-activated protein kinase – development of the energy sensor concept. Hardie DG, Hawley SA, Scott JW. J Physiol 574.1 pp 7-15. [See]

PPAR and human metabolic disease.Semple RK, Chatterjee VK, Rahilly SO. J. Clin. Invest. 2006;116:581-589. [See]

Insulin, Insulin-Like Growth Factors and Colon Cancer: A Review of the Evidence.  Giovannucci E. J. Nutr. 2001;131:3109S-3120S. [See]

Insulin resistance and breast-cancer risk.  Bruning PF et al. Int J Cancer. 1992;52(4):511-6. [See]

Glycemic index, hyperinsulinemia, and breast cancer risk. Key TJ. Annals of Oncology 2001;12:1507-1509. [See]

The Dietary Glycemic Index and its Implications in Cancer Risk, Insulin-Like Growth Factors and Oxidative Stress. Augustin LSA. University of Guelph. 2010. [See]

Dietary glycemic index and glycemic load, and breast cancer risk A case-control study.  Augustin LSA, Dal Maso L, La Vecchia C et al. Ann Oncol 2001;12:1533-1538. [See]

Diet, lifestyle, and colorectal cancer: is hyperinsulinemia the missing link? Kim YI. Nutr Rev. 1998;56(9):275-279. [See]

Metabolic syndrome affects breast cancer risk in postmenopausal women: National Cancer Institute of Naples experience. Capasso I et al. Cancer Biology & Therapy 2010;10(12):1240-1243. [See]

Nutrition, Insulin, Insulin-like Growth Factors and Cancer. Giovannucci E. Horm Metab Res 2003;35:694-704. [See]

Hyperinsulinemia in colon, stomach and breast cancer patients. Yam D et al. Cancer Lett. 1996;104(2):129-132. [See]

Insulin and colon cancer. Giovannucci E. Cancer Causes and Control 1995;6(2):164-179. [See]

Hyperinsulinemia in patients with colorectal cancer. Suehiro T et al. Hepatogastroenterology. 2005;52(61):76-78. [See]

Hyperinsulinemic diseases of civilization: more than just syndrome X.  Cordain L, Eades MR, Eades MD. Comp Biochem Physiol Part A. 2003;136:95-112. [See]

Metabolic Syndrome: Pathophysiology and Implications for Management of Cardiovascular Disease. Reaven G. Circulation. 2002;106:286. [See]

Insulin Resistance Syndrome. Rao G. American Family Physician. 2001;63(6). [See]

Obesity, Body Fat Distribution, Insulin Sensitivity and Islet -Cell Function as Explanations for Metabolic Diversity. Kahn SE et al. Journal of Nutrition. 2001;131:354S-360S. [See]

Insulin resistance and cardiovascular disease. Ginsberg HN. J Clin Inv. 2000;106(4):453-458. [See]

Effect of Intra-arterial Insulin on Tissue Cholesterol and Fatty Acids in Alloxan-Diabetic Dogs.  Cruz AB et al. Circulation Research. 1961;9:39. [See]

Insulin Causes Endothelial Dysfunction in Humans – Sites and Mechanisms.  Arcaro G et al. Circulation. 2002;105:576. [See]

Enhanced secretion of insulin plays a role in the development of atherosclerosis and restenosis of coronary arteries: elective percutaneous transluminal coronary angioplasty in patients with effort angina.  Nishimoto Y et al. J Am Coll Cardiol. 1998;32:1624-1629. [See]

Antihypertensive therapy and insulin sensitivity: do we have to redefine the role of beta-blocking agents? Jacob S, Rett K, Henriksen EJ. Am J Hypertens. 1998;11(10):1258-65. [See]

Hyperinsulinemia, insulin resistance, and the treatment of hypertension. Lithell HO. Am J Hypertens. 1996 Nov;9(11):150S-154S. [See]

Management of the metabolic syndrome.  Scheen AJ. Minerva Endocrinol. 2004 Jun;29(2):31-45. [See]

Glucose tolerance and insulin action in healthy centenarians. Paolisso G et al. Am J Physiol Endocrinol Metab 1996;270:E890-E894. [See]

Sex steroids and insulin resistance. Livingstone C, Collison M. Clinical Science. 2002;102:151–166. [See]

Exenatide, the new drug for diabetes, may cause pancreatitis: See Report

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